Download e-book for kindle: 100 Years of Virology: The Birth and Growth of a Discipline by A. van Kammen (auth.), Prof. Dr. Charles H. Calisher, Prof.

By A. van Kammen (auth.), Prof. Dr. Charles H. Calisher, Prof. Dr. M. C. Horzinek (eds.)

ISBN-10: 3211833609

ISBN-13: 9783211833605

ISBN-10: 3709164257

ISBN-13: 9783709164259

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Schlesinger (1932), German virology after Loeffler 47 the first step leading to phage adsorption [13]. In 1954, W. Weidel presented the first evidence for the nature of a corresponding bacterial receptor [14]. G. Koch (1958) characterised as a lysozyme the enzyme responsible for phage release from a bacterial cell by lysis-from-within [15]. From all studies it became clear that viruses are autoreproductive particles ranging in size from the smallest bacteria to the largest known biologically active macromolecules.

He then succeeded in isolating and purifying several other viroids, resulting in a detailed biochemical, physicochemical and morphological characterisation. Thus, in collaboration with G. Klotz, D. Riesner, H. J. Gross and A. K. Kleinschmidt [51] he was able to demonstrate in 1976 that "viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures" with a molecular weight of 120,000 corresponding to ca. 360 nucleotides. In 1978 both the nucleotide sequence and secondary structure of the first viroid RNA was published [52].

The remembrance of that time, when we were still working ... in the middle Robert Koch and we at his side, when we were faced almost daily with new miracles of bacteriology and when we - following our principal's shining example - were working from dawn to dusk hardly finding time to meet the physical requirements, the remembrance of that time I shall never forget. Surely 26 W. Wittmann Fig. 1. 4. " (Fig. I) Uhlenhuth, Loeffler's most recent co-worker said in memoriam [60]: " ... when he succeeded in finding a new staining method ...

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100 Years of Virology: The Birth and Growth of a Discipline by A. van Kammen (auth.), Prof. Dr. Charles H. Calisher, Prof. Dr. M. C. Horzinek (eds.)


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